Tirzepatide (60mg) Injectable

Weight Loss and Metabolic Health
- Promotes fat burning by enhancing the body's ability to use stored fat as energy.
- Reduces appetite and increases feelings of fullness (satiety), leading to reduced caloric intake.
- Supports long-term weight management by decreasing body mass index (BMI).
Improves insulin sensitivity, reducing fat storage and supporting overall metabolic health.

Cardiovascular Benefits
- Reduce the risk of major adverse cardiovascular events (MACE) in patients with type 2 diabetes
- Lower rates of non-fatal myocardial infarction, non-fatal stroke, and cardiovascular death
- Improve heart health by reducing blood pressure and improving endothelial function
- Potential benefits for heart failure patients, particularly those with preserved ejection fraction

Renal Benefits
- Reduce the risk of renal diseases in type 2 diabetes patients
- Improve renal function in animal models of kidney damage

Anti-inflammatory Effects
- Reduce systemic inflammation
- Decrease inflammation in the small and large intestines

Cancer Risk Reduction
- Lower the risk of certain cancers (pancreatic, colorectal, breast)
- Suppress tumor cell proliferation and induce cell death

Glycemic Control
- Effectively lower blood glucose levels without causing hypoglycemia
- Stimulate insulin release and suppress glucagon secretion
- Improve beta cell survival and function

Hepatic Benefits
- Potential to reduce the incidence of metabolic liver diseases
- Decrease liver inflammation in patients with fatty liver disease

Neurological and Psychiatric Effects
- Reducing neuroinflammation and neurodegeneration
- Possible therapeutic effects in Parkinson's disease
- Potential improvements in Alzheimer's and other cognitive disorders

Addiction and Behavioral Health
- Reducing alcohol consumption (though results are mixed)
- Possibly improving symptoms related to drug abuse and compulsive behaviors

History of Pancreatitis: Individuals with a history of this condition should consult their healthcare provider.

Pregnant or Breastfeeding Women: The safety of Tirzepatide during pregnancy or breastfeeding has not been established, so it is contraindicated in these populations.

Severe Gastrointestinal Disease: People with conditions like gastroparesis should consult their healthcare provider as it slows gastric emptying and could exacerbate symptoms.

History of Medullary Thyroid Carcinoma: Individuals with a personal or family history of medullary thyroid carcinoma should consult their healthcare provider.

Multiple Endocrine Neoplasia Syndrome Type 2 (MEN 2): Individuals with MEN 2 are at increased risk of thyroid tumors.

Metabolic Health & Weight Loss: Obesity, Type 2 diabetes, pre-diabetes, metabolic syndrome, insulin resistance, hyperlipidemia.

Cardiovascular Health: Hypertension, dyslipidemia, cardiovascular disease, atherosclerosis.

Endocrine & Hormonal Conditions: Polycystic ovary syndrome (PCOS), non-alcoholic fatty liver disease (NAFLD), menopausal weight gain, hormone-driven insulin resistance.

Mental Health: Depression, anxiety, stress-induced eating, and cravings linked to blood sugar fluctuations.

Addiction & Craving Management: Nicotine, alcohol, sugar cravings, binge eating.
Anti-Inflammatory & Chronic Conditions: Chronic inflammation, osteoarthritis, joint pain.

Injection Site: Administer injections into subcutaneous fat (such as the stomach, thigh, or arm).

Time of Day: Tirzepatide can be injected any time of day. Some people prefer to time their weekly dosing on a weekend or time anticipating some side effects especially when first beginning.

OPTION 1: BASELINE LONGEVITY LOW DOSE

ONE INJECTION PER WEEK (Most Common):

2.5 mg = 25 units per injection.

The standard low dose is 25 units (2.5 mg) weekly. Vial duration lasts 24 weeks at this dose and frequency.

Pros: Simple, easy to remember, requires less frequent injections.
Cons: May lead to stronger side effects in some individuals.

TWO INJECTIONS PER WEEK:

1.25 mg = 12.5 units per injection.

Vial duration lasts 24 weeks at this dose and frequency.

Pros: Reduced side effects, more stable medication levels.
Cons: Requires more injections and planning.

OPTION 2: WEIGHT LOSS

General Dosing Instructions:

The recommended starting dose is 25 units (2.5 mg) weekly,        with a gradual increase until your desired dose is reached. Many individuals choose to increase their dose by one tier every 2-4 weeks based on their tolerance and health goals. Once desired weight loss goals are reached, it is advised to slowly reduce the dose and continue taking a lower dose for ongoing metabolic and longevity benefits.



COMMON DOSING TIERS

1.25mg --> 12.5 units

2.5mg --> 25 units

5mg --> 50 units

7.5mg --> 75 units

10mg --> 100 units

12.5mg --> 125 units

15mg --> 150 units

Nausea: A common side effect, particularly during the initial stages of treatment, as the body adjusts to the medication.

Diarrhea: Gastrointestinal disturbances like diarrhea can occur, especially with higher doses or dose escalation.

Decreased Appetite: While decreased appetite can be beneficial for weight loss, it is imperative to ensure you are consuming an efficient amount of calories and nutrients.

Vomiting: In some cases, patients may experience vomiting, particularly if doses are increased too quickly.

Constipation: Less frequently, constipation may occur as the digestive system adjusts to slower gastric emptying.

Start with a Low Dose: Begin with the lowest recommended dose to help the body adapt and reduce gastrointestinal side effects like nausea and vomiting.

Split Doses Throughout the Week: Dividing the weekly dose into 2-5 smaller injections can help maintain a steady hormone level and reduce side effects.

Administer Before Meals: Taking the injection before meals can help ease gastrointestinal discomfort by slowing gastric emptying.

Stay Hydrated: Drinking plenty of water can alleviate symptoms like nausea and is crucial for maintaining hydration, especially if experiencing diarrhea or vomiting.

Gradually Increase Dosage: Gradually increasing the dose over several weeks helps the body adjust better, reducing the intensity of side effects.

Focus on High-Protein, Smaller Meals: Eating smaller, high-protein meals can reduce gastrointestinal symptoms by easing the digestive load.

Consider Adding Other Peptides or Vitamins: Adding growth hormone peptides or other supplements may enhance the effects of GLP-1 peptides and optimize body composition.

Monitor Progress: Regular Dexa scans and blood tests can help track progress, ensuring sufficient nutrient intake, maintaining muscle mass, and promoting long-term health.

GLP-1s work by mimicking the natural hormone GLP-1 in the body, which helps regulate blood sugar and appetite. These peptides slow gastric emptying, enhance satiety, and improve insulin sensitivity, which is key for managing diabetes and preventing metabolic syndrome. They also help reduce harmful cravings, from sugar to nicotine, further supporting healthier lifestyle habits.

GLP-1 peptides are well-known for their ability to aid in weight loss and manage metabolic conditions such as diabetes, but their benefits go beyond these primary uses. GLP-1 peptides regulate insulin, reduce inflammation, improve hormone regulation, enhance mental health, stabilize energy levels, and support cardiovascular health. Even if a patient does not want to lose weight, GLP-1s offer significant benefits for longevity when taken in low doses, making them a valuable addition to many peptide protocols.