Semaglutide (5mg) Injectable

Weight Loss and Metabolic Health
- Promotes fat burning by enhancing the body's ability to use stored fat as energy.
- Reduces appetite and increases feelings of fullness (satiety), leading to reduced caloric intake.
- Supports long-term weight management by decreasing body mass index (BMI).
Improves insulin sensitivity, reducing fat storage and supporting overall metabolic health.

Cardiovascular Benefits
- Reduce the risk of major adverse cardiovascular events (MACE) in patients with type 2 diabetes
- Lower rates of non-fatal myocardial infarction, non-fatal stroke, and cardiovascular death
- Improve heart health by reducing blood pressure and improving endothelial function
- Potential benefits for heart failure patients, particularly those with preserved ejection fraction

Renal Benefits
- Reduce the risk of renal diseases in type 2 diabetes patients
- Improve renal function in animal models of kidney damage

Anti-inflammatory Effects
- Reduce systemic inflammation
- Decrease inflammation in the small and large intestines

Cancer Risk Reduction
- Lower the risk of certain cancers (pancreatic, colorectal, breast)
- Suppress tumor cell proliferation and induce cell death

Glycemic Control
- Effectively lower blood glucose levels without causing hypoglycemia
- Stimulate insulin release and suppress glucagon secretion
- Improve beta cell survival and function

Hepatic Benefits
- Potential to reduce the incidence of metabolic liver diseases
- Decrease liver inflammation in patients with fatty liver disease

Neurological and Psychiatric Effects
- Reducing neuroinflammation and neurodegeneration
- Possible therapeutic effects in Parkinson's disease
- Potential improvements in Alzheimer's and other cognitive disorders

Addiction and Behavioral Health
- Reducing alcohol consumption (though results are mixed)
- Possibly improving symptoms related to drug abuse and compulsive behaviors

History of Pancreatitis: Individuals with a history of this condition should consult their healthcare provider.

Pregnant or Breastfeeding Women: The safety of Tirzepatide during pregnancy or breastfeeding has not been established, so it is contraindicated in these populations.

Severe Gastrointestinal Disease: People with conditions like gastroparesis should consult their healthcare provider as it slows gastric emptying and could exacerbate symptoms.

History of Medullary Thyroid Carcinoma: Individuals with a personal or family history of medullary thyroid carcinoma should consult their healthcare provider.

Multiple Endocrine Neoplasia Syndrome Type 2 (MEN 2): Individuals with MEN 2 are at increased risk of thyroid tumors.

Metabolic Health & Weight Loss: Effective for managing obesity, type 2 diabetes, pre-diabetes, metabolic syndrome, insulin resistance, and hyperlipidemia.

Cardiovascular Health: Supports hypertension management, improves lipid profiles, and reduces cardiovascular disease risk.

Hormonal Conditions: Helps manage PCOS, non-alcoholic fatty liver disease (NAFLD), and menopausal weight gain.

Mental Health: Assists with depression, anxiety, and stress-induced eating, which are often linked to blood sugar fluctuations.

Addiction & Craving Management: Helps reduce nicotine, alcohol, sugar cravings, and binge eating.

Anti-Inflammatory & Chronic Conditions: Addresses chronic inflammation, osteoarthritis, and joint pain.

Injection Site: Administer injections into subcutaneous fat (such as the stomach, thigh, or arm).

Time of Day: Semaglutide can be injected any time of day. Some people prefer to time their weekly dosing on a weekend or time anticipating some side effects especially when first beginning.

OPTION 1: BASELINE LONGEVITY LOW DOSE

ONE INJECTION PER WEEK (Most Common):

0.25 mg = 12.5 units per injection.

The standard low dose is 12.5 units (0.25 mg) weekly. Vial duration lasts 20 weeks at this dose and frequency.

Pros: Simple, easy to remember, requires less frequent injections.
Cons: May lead to stronger side effects in some individuals.

TWO INJECTIONS PER WEEK:

0.125 mg = 6.25 units per injection.

Vial duration lasts 20 weeks at this dose and frequency.

Pros: Reduced side effects, more stable medication levels.
Cons: Requires more injections and planning.

OPTION 2: WEIGHT LOSS

General Dosing Instructions:

The recommended starting dose is 12.5 units (0.25 mg) weekly,   with a gradual increase until your desired dose is reached. Many individuals choose to increase their dose by one tier every 2-4 weeks based on their tolerance and health goals. Once desired weight loss goals are reached, it is advised to slowly reduce the dose and continue taking a lower dose for ongoing metabolic and longevity benefits

COMMON DOSING TIERS

0.25mg --> 12.5 units

0.5mg --> 25 units

1.0mg --> 50 units

1.5mg --> 75 units

2.0mg --> 100 units

2.4mg --> 120 units

Nausea: A common side effect, particularly during the initial stages of treatment, as the body adjusts to the medication.

Diarrhea: Gastrointestinal disturbances like diarrhea can occur, especially with higher doses or dose escalation.

Decreased Appetite: While decreased appetite can be beneficial for weight loss, it is imperative to ensure you are consuming an efficient amount of calories and nutrients.

Vomiting: In some cases, patients may experience vomiting, particularly if doses are increased too quickly.

Constipation: Less frequently, constipation may occur as the digestive system adjusts to slower gastric emptying.

Start with a Low Dose: Begin with the lowest recommended dose to help the body adapt and reduce gastrointestinal side effects like nausea and vomiting.

Split Doses Throughout the Week: Dividing the weekly dose into 2-5 smaller injections can help maintain a steady hormone level and reduce side effects.

Administer Before Meals: Taking the injection before meals can help ease gastrointestinal discomfort by slowing gastric emptying.

Stay Hydrated: Drinking plenty of water can alleviate symptoms like nausea and is crucial for maintaining hydration, especially if experiencing diarrhea or vomiting.

Gradually Increase Dosage: Gradually increasing the dose over several weeks helps the body adjust better, reducing the intensity of side effects.

Focus on High-Protein, Smaller Meals: Eating smaller, high-protein meals can reduce gastrointestinal symptoms by easing the digestive load.

Consider Adding Other Peptides or Vitamins: Adding growth hormone peptides or other supplements may enhance the effects of GLP-1 peptides and optimize body composition.

Monitor Progress: Regular Dexa scans and blood tests can help track progress, ensuring sufficient nutrient intake, maintaining muscle mass, and promoting long-term health.

GLP-1s work by mimicking the natural hormone GLP-1 in the body, which helps regulate blood sugar and appetite. These peptides slow gastric emptying, enhance satiety, and improve insulin sensitivity, which is key for managing diabetes and preventing metabolic syndrome. They also help reduce harmful cravings, from sugar to nicotine, further supporting healthier lifestyle habits.