Pentosan PPS (250mg/mL) Injectable
Pentosan Polysulfate Sodium (PPS) is an injectable peptide with anti-inflammatory, cartilage-protective, and regenerative effects. Originally used to treat interstitial cystitis, it is now recognized for its joint-supportive properties, pain relief, and ability to enhance tissue repair.
Unlike NSAIDs or steroids that only mask pain, Pentosan targets the root cause of joint damage, helping to regenerate cartilage, improve circulation, and reduce inflammation. It is used by athletes, individuals with arthritis, and those looking to maintain long-term joint health.
5mL per vial. 1250mg per vial.
Lasts ~5 weeks at standard dose and frequency.
▫ Supports Joint Repair & Cartilage Health – Helps slow joint degradation and supports repair.
▫ Potent Anti-Inflammatory Effects – Reduces systemic and localized inflammation.
▫ Pain Reduction – Can alleviate chronic joint pain and stiffness without NSAIDs or steroids.
▫ Improves Mobility & Function – Enhances flexibility, movement, and physical activity levels.
▫ Fibrinolytic & Cardiovascular Benefits – May enhance blood flow and reduce micro-clots.
▫ Alternative to NSAIDs & Corticosteroids – A well-tolerated, long-term solution for joint support.
▫ Active bleeding disorders or patients on anticoagulants (e.g., Warfarin, Heparin).
▫ History of heparin-induced thrombocytopenia (HIT).
▫ Pregnancy or breastfeeding (safety is not well established).
▫ Injection Site Reactions – Minor swelling or redness; rotate sites to prevent irritation.
▫ Mild GI Upset – Stay hydrated and eat before injections if needed.
▫ Increased Bruising or Nosebleeds (Rare) – Monitor if using blood thinners.
▫ Headache or Dizziness (Uncommon) – Ensure proper electrolyte balance.
▫ Allergic Reaction (Very Rare) – Seek immediate medical help if severe symptoms occur.
▫ Injection Site Reactions – Minor swelling or redness; rotate sites to prevent irritation.
▫ Mild GI Upset – Stay hydrated and eat before injections if needed.
▫ Increased Bruising or Nosebleeds (Rare) – Monitor if using blood thinners.
▫ Headache or Dizziness (Uncommon) – Ensure proper electrolyte balance.
▫ Allergic Reaction (Very Rare) – Seek immediate medical help if severe symptoms occur.
▫ Supports cartilage regeneration by stimulating chondrocyte activity.
▫ Reduces inflammation by modulating inflammatory cytokines.
▫ Improves joint lubrication by increasing proteoglycan synthesis.
▫ Enhances circulation & fibrinolysis, reducing clot formation and microvascular inflammation.
▫ Provides long-term pain relief without the risks of NSAIDs or opioids.
▫ Week 2-4 – Initial pain relief, reduction in joint stiffness, and inflammation.
▫ Week 6-8 – Increased mobility and functional improvement in joint health.
▫ Week 12 – Peak benefits, with enhanced cartilage integrity and sustained pain relief.
▫ Post-Cycle – Benefits may persist for months, with periodic cycles recommended for long-term joint health.
Consult your healthcare provider for patient specific dosing.
STANDARD DOSING
Inject 50 units (125mg) 2x weekly, 3 months on followed by a 1 month break.
INJECTION SITE
Subcutaneous (stomach, thigh, or upper arm).
TIME OF DAY
Can be injected any time of day, ideally 1-2 hours after your last meal.
Peptide Reconstitution Guide
This guide is designed to help you reconstitute your powdered peptide vials to prepare them for injection.
